In VitroPubMed ID: 16085411·2005

Thymosin Beta-4 Increases Vascular Permeability and Leukocyte Extravasation

Grant DS, Long GL, Isfan F, et al.

Microcirculation, 2005 · n = 3

Key finding

TB-500 increased VEGF-induced vascular permeability 2.8-fold, enhanced neutrophil transmigration through endothelium 4.1-fold.

Summary

TB-500 enhanced endothelial cell permeability and supported immune cell infiltration beneficial for tissue repair.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

TB-500L3

A naturally occurring peptide central to cell migration and tissue repair. Phase 2 human wound healing trials showed accelerated healing; also studied for cardiac and corneal repair.

More research on TB-500

The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients

Annals of the New York Academy of Sciences · 2012 · Human Pilot

TB-500 Improves Neurological Recovery After Traumatic Brain Injury

Journal of Neurotrauma · 2011 · Animal Study

Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications

Expert Opinion on Biological Therapy · 2010 · Review

Thymosin Beta-4 Regulates Inflammation and Promotes Macrophage M2 Polarization

Journal of Molecular Medicine · 2010 · In Vitro

Thymosin beta4 and cardiac repair

Annals of the New York Academy of Sciences · 2009 · Animal Study