Animal StudyPubMed ID: 16488018·2006

ACTH 4-10 and Semax: Modulation of Dopamine and Norepinephrine Systems in Brain Reward Pathways

Ashmarin IP, Kamayev YA, Lyapina LA.

Neurochemistry International, 2006

Key finding

Semax increased VTA dopamine 156% and nucleus accumbens dopamine 123%; increased prefrontal norepinephrine 89%.

Summary

Microdialysis study measuring semax effects on ventral tegmental area and nucleus accumbens dopamine, as well as prefrontal norepinephrine.

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Related compound

SemaxL3

A synthetic peptide analog of ACTH(4-10) approved in Russia as a nootropic, studied for cognitive enhancement and neuroprotection.

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