Animal StudyPubMed ID: 17383604·2007

Intranasal Semax Bioavailability and Mechanism of Olfactory Epithelium-to-Brain Delivery

Lyapina LA, Kamayev YA, Ashmarin IP.

Brain Research, 2007

Key finding

Intranasal semax reached brain olfactory bulb in 2 minutes and spread throughout CNS; trans-synaptic transport documented.

Summary

Study documenting olfactory nerve fiber-mediated transport of intranasal semax directly to CNS, bypassing blood-brain barrier.

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Related compound

SemaxL3

A synthetic peptide analog of ACTH(4-10) approved in Russia as a nootropic, studied for cognitive enhancement and neuroprotection.

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