Human PilotPubMed ID: 17452735·2007

MK-677 immunological effects: T-cell and B-cell function in aged subjects

Dixit VD, Yang H, Sun Y, et al.

Journal of Gerontology: Series A, 2007 · n = 28

Key finding

MK-677 increased naive T-cell numbers by 24% and improved T-cell proliferative response; no effect on antibody titers.

Summary

Small study examining MK-677 effects on cell-mediated and humoral immunity in elderly subjects using lymphocyte phenotyping and function tests.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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