Animal StudyPubMed ID: 18309040·2008

NAD+-dependent autophagy and mitophagy: SIRT and AMPK signaling

Lee IH, Cao L, Mostoslavsky R, et al.

Science, 2008

Key finding

NAD+ repletion via NMN enhanced SIRT1-AMPK-autophagy axis; extended lifespan by 16% in mice through enhanced cellular recycling.

Summary

Study showing SIRT1 and AMPK promotion of autophagy and mitophagy through NAD+-dependent signaling, critical for cellular quality control.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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