ReviewPubMed ID: 33353981·2021

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias AJ, et al.

Nature Reviews Molecular Cell Biology, 2021

Key finding

NAD+ levels decline with age across species, and restoring NAD+ has shown benefits in animal models for multiple aging-related conditions.

Summary

Comprehensive review of NAD+ decline with aging and its role in cellular processes including sirtuins, PARP, and CD38.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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