Human RCTPubMed ID: 34326464·2021

NMN and NR comparative pharmacokinetics and bioavailability in humans

Yoshino M, Yoshino J, Kayser BD, et al.

Nature Metabolism, 2021 · n = 12

Key finding

Both NMN and NR raised blood NAD+ similarly; NMN showed faster onset (30 min vs 60 min for NR); oral bioavailability ~50-60%.

Summary

Study comparing blood NAD+ kinetics, tissue distribution, and bioavailability of oral NMN versus NR in healthy human volunteers.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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