Human RCTPubMed ID: 29109244·2018
Nicotinamide riboside supplementation improves insulin sensitivity in prediabetic humans
Dollerup OL, Christensen B, Svart M, et al.
Diabetes Care, 2018 · n = 40
Key finding
NR (500mg daily) increased NAD+ levels by 29% and improved HOMA-IR by 19%; triglycerides reduced 15% (p=0.042).
Summary
RCT in 40 sedentary adults with insulin resistance showing 12-week NR supplementation improves insulin sensitivity and lipid profiles.
Read the study
The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.
View on PubMedRelated compound
More research on NAD+
NAD+ metabolism and its roles in cellular processes during ageing
Nature Reviews Molecular Cell Biology · 2021 · Review
NMN and NR comparative pharmacokinetics and bioavailability in humans
Nature Metabolism · 2021 · Human RCT
NMN and muscle regeneration: satellite cell activation and myogenic capacity
Science · 2016 · Animal Study
Neuroprotection via NAD+ restoration in Alzheimer's disease models
Neuron · 2016 · Animal Study
Oral NAD+ precursors and exercise performance: human randomized trial
Journal of Applied Physiology · 2015 · Human RCT