ReviewPubMed ID: 18374337·2008

NAD+ biosynthetic pathway enzymes and aging: de novo vs salvage pathways

Bogan KL, Brenner C.

Annual Review of Nutrition, 2008

Key finding

Aging preferentially impairs salvage pathway; oral NAD+ precursors more efficiently restore NAD+ than dietary tryptophan.

Summary

Comprehensive review of NAD+ biosynthesis via de novo (from tryptophan) and salvage (from NMN, NR) pathways and age-related changes.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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