Animal StudyPubMed ID: 18472348·2008

Semax Enhances Neurogenesis and Hippocampal Plasticity in Aging Rats

Arushanian EB, Stepanov SS, Ashmarin IP, et al.

Neuroscience, 2008

Key finding

Semax increased newborn neurons 2.1-fold, increased doublecortin+ cells 67%, increased synaptic density 48%, and improved water maze performance.

Summary

Study in aged rats examining semax effects on hippocampal neurogenesis (BrdU+, doublecortin+), BDNF, and synaptic density.

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Related compound

SemaxL3

A synthetic peptide analog of ACTH(4-10) approved in Russia as a nootropic, studied for cognitive enhancement and neuroprotection.

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