Animal StudyPubMed ID: 18945921·2008

ACTH 4-10 Analog Semax Increases BDNF Signaling and Promotes Neuroplasticity in Ischemic Brain Damage

Skvortsova VI, Dambinova SA, Gusev EI.

The Journal of Neuroscience, 2008

Key finding

Semax increased brain BDNF expression 3.2-fold, increased phospho-TrkB 2.8-fold, and enhanced synaptic density (synaptophysin +45%).

Summary

Mechanistic study in rats with transient middle cerebral artery occlusion examining semax effects on BDNF, TrkB activation, and synaptic plasticity.

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Related compound

SemaxL3

A synthetic peptide analog of ACTH(4-10) approved in Russia as a nootropic, studied for cognitive enhancement and neuroprotection.

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