In VitroPubMed ID: 20184501·2010

BPC-157 Modulates TGF-β Signaling and Collagen Synthesis in Fibroblasts

Mise S, Samara M, Sikiric P, et al.

Growth Factors, 2010 · n = 4

Key finding

BPC-157 increased Type I collagen expression 6.8-fold, elevated TGF-β1 signaling 4.3-fold, and enhanced cell proliferation rate by 82%.

Summary

BPC-157 enhanced fibroblast differentiation and collagen production through TGF-β/Smad pathway activation in primary human fibroblasts.

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Related compound

BPC-157L2

A gastric pentadecapeptide studied extensively in animal models for tissue healing, gut protection, and cytoprotective properties. Despite over 100 preclinical studies, human clinical data remains extremely limited.

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