In VitroPubMed ID: 20346760·2010

NAD+-dependent deacetylation of mitochondrial proteins: SIRT3 and SIRT4 effects

Hirschey MD, Shimazu T, Huang JY, et al.

Cell Metabolism, 2010

Key finding

NAD+-dependent SIRT3 deacetylation of acetyl-CoA synthetase and isocitrate dehydrogenase enhanced mitochondrial oxidative capacity 34%.

Summary

Mechanistic study of SIRT3 and SIRT4 deacetylation of mitochondrial proteins and effects on energy metabolism and oxidative stress.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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