In VitroPubMed ID: 20430055·2010

BPC-157 Prevents Nitric Oxide Synthase Dysfunction and Endothelial Injury

Sikiric P, Mise S, Drmic D, et al.

Regulatory Peptides, 2010 · n = 3

Key finding

BPC-157 preserved eNOS activity by 78%, increased NO production from 15% (LPS alone) to 82% of controls, and reduced ROS generation by 65%.

Summary

BPC-157 protected against LPS-induced endothelial dysfunction and restored nitric oxide production in cultured human endothelial cells.

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Related compound

BPC-157L2

A gastric pentadecapeptide studied extensively in animal models for tissue healing, gut protection, and cytoprotective properties. Despite over 100 preclinical studies, human clinical data remains extremely limited.

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