Animal StudyPubMed ID: 20816886·2010

NAD+-dependent histone deacetylation and gene expression in aging

Schug TT, Xu Q, Gao H, et al.

Cell Metabolism, 2010

Key finding

Aging reduced SIRT1-mediated histone H3K9 deacetylation; NMN restored SIRT activity and reversed age-associated transcriptional changes.

Summary

Mechanistic study of age-related changes in SIRT-mediated histone deacetylation and effects on gene expression programs.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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