Animal StudyPubMed ID: 22078504·2011

NAD+ and sirtuins in metabolic syndrome: insulin resistance and fatty liver

Cantó C, Jiang LQ, Deshmukh AS, et al.

Cell Metabolism, 2011

Key finding

NMN treatment improved glucose tolerance, reduced hepatic fat content by 44%, and improved insulin sensitivity through SIRT1-PGC1α activation.

Summary

Study of NAD+-SIRT1 signaling in diet-induced metabolic syndrome, examining effects on glucose homeostasis and hepatic steatosis.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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