ReviewPubMed ID: 22285848·2012

NAD+ metabolism and DNA repair: PARP activation and genomic stability

Bai P, Cantó C.

FEBS Letters, 2012

Key finding

Aging-related NAD+ decline compromises PARP-mediated DNA repair; NAD+ restoration restores genomic stability and lifespan in model organisms.

Summary

Comprehensive review of NAD+-dependent PARP activity in DNA repair, examining age-related NAD+ decline and therapeutic implications.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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