Animal StudyPubMed ID: 25848866·2015

NAD+ and CD38 enzymatic activity in immune cells: aging and inflammation

Guerreiro RJ, Lohm S, Tan C, et al.

Immunity, 2015

Key finding

Aged mice showed elevated CD38 expression (1.9-fold) and lower NAD+; NMN restored NAD+ levels and improved T-cell response to vaccination.

Summary

Study of CD38 NAD+-consuming enzyme in aged immune cells and effects of NAD+ repletion on T-cell function and inflammatory responses.

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Related compound

NAD+L3

A coenzyme critical for cellular energy and DNA repair. Not technically a peptide, but commonly discussed alongside peptide therapies in the longevity space.

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