Animal StudyPubMed ID: 35715704·2022

MOTS-c peptide administration enhances mitochondrial biogenesis in skeletal muscle

Lee C, Zeng D, Dibble C, et al.

Nature Metabolism, 2022

Key finding

MOTS-c 10ng/kg daily for 8 weeks increased mitochondrial DNA copy number by 2.3-fold and citrate synthase activity by 1.8-fold in skeletal muscle.

Summary

Study showing MOTS-c subcutaneous injections increase mitochondrial density, cristae organization, and oxidative capacity in mouse soleus and gastrocnemius muscles.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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