MOTS-c enhances glucose uptake through AMPK-independent mechanisms in muscle
Sripada L, Zhang K, Yen K, et al.
Metabolism: Clinical & Experimental, 2024
Key finding
MOTS-c increased basal glucose uptake by 48% in myotubes; AMPK inhibition reduced this to 31%, indicating 65% AMPK-dependent and 35% AMPK-independent effects.
Summary
Study examining MOTS-c effects on GLUT4 translocation and glucose uptake in myotubes with selective AMPK inhibition to identify independent mechanisms.
Read the study
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