Animal StudyPubMed ID: 38391847·2024

Mitochondrial-derived peptide MOTS-c mediates beneficial metabolic effects of exercise

Yen K, Christensen MM, Wakshlag JJ, et al.

Cell Reports, 2024

Key finding

MOTS-c increased by 85% in voluntary running mice; exogenous MOTS-c in sedentary mice improved glucose tolerance (AUC reduction 18%) and increased PGC-1α expression 2.1-fold.

Summary

Mechanistic study demonstrating MOTS-c is both elevated during exercise and sufficient to mediate exercise-like metabolic benefits without exercise.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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