Animal StudyPubMed ID: 38521847·2024

MOTS-c and liver metabolism: effects on hepatic glucose production and lipid metabolism

Sripada L, Ye Q, Xiao T, et al.

Journal of Hepatology, 2024

Key finding

MOTS-c reduced hepatic glucose production by 32% in fed state and suppressed VLDL secretion; modest effect on hepatic fat content unless combined with diet intervention.

Summary

Study of MOTS-c effects in hepatocytes and whole-animal models examining glucose production, fatty acid oxidation, and VLDL secretion.

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The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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