Animal StudyPubMed ID: 36997521·2023

MOTS-c dosing optimization and pharmacodynamics in obesity models

Yen K, Christensen MM, Sripada L, et al.

Molecular Metabolism, 2023

Key finding

Optimal dose 10ng/kg daily; effect plateaued above 30ng/kg; metabolic benefits apparent within 2 weeks, sustained for 12 weeks with continued treatment.

Summary

Dose-response and time-course studies of MOTS-c in diet-induced and genetic obesity models with frequent metabolic monitoring.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

More research on MOTS-c

Human pilot study: MOTS-c supplementation improves insulin sensitivity

Journal of Clinical Endocrinology & Metabolism · 2025 · Human Pilot

Mitochondrial-derived peptide MOTS-c mediates beneficial metabolic effects of exercise

Cell Reports · 2024 · Animal Study

MOTS-c analog development and pharmacokinetics: oral bioavailability enhancement

Biochemical Pharmacology · 2024 · Animal Study

MOTS-c enhances glucose uptake through AMPK-independent mechanisms in muscle

Metabolism: Clinical & Experimental · 2024 · Animal Study

MOTS-c and liver metabolism: effects on hepatic glucose production and lipid metabolism

Journal of Hepatology · 2024 · Animal Study