Animal StudyPubMed ID: 37039482·2023

MOTS-c and aerobic capacity: effects on mitochondrial respiratory efficiency

Christensen MM, Wang K, Yen K, et al.

American Journal of Physiology - Cell Physiology, 2023

Key finding

MOTS-c treatment increased P/O ratio from 2.1 to 2.4 (14% improvement) and enhanced ATP synthesis rate by 18% in skeletal muscle mitochondria.

Summary

Measurement of oxygen consumption rates in isolated mitochondria and whole animals treated with MOTS-c, examining P/O ratios and ATP synthesis efficiency.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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