In VitroPubMed ID: 37043982·2023

MOTS-c in cellular stress resistance: protection against oxidative stress and mitochondrial dysfunction

Zhu XH, Moreau R, Ouellette M, et al.

Redox Biology, 2023

Key finding

MOTS-c pretreatment reduced H2O2-induced ROS accumulation by 54% and restored mitochondrial membrane potential (ΔΨm) from 67% to 91% of baseline.

Summary

Cellular studies showing MOTS-c protects myotubes and fibroblasts from H2O2-induced oxidative damage and improves mitochondrial membrane potential.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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