In VitroPubMed ID: 37159284·2023

Mitochondrial targeting and cellular uptake mechanisms of MOTS-c peptide

Kim SJ, Ryu D, Schultze JL, et al.

Molecular Therapy - Methods & Clinical Development, 2023

Key finding

MOTS-c enters cells via clathrin-mediated endocytosis and a non-receptor mechanism; 12-15% reaches mitochondrial matrix; accumulates with repeated dosing.

Summary

Mechanistic study of MOTS-c cellular internalization, mitochondrial targeting sequences, and receptor-mediated versus non-receptor-mediated uptake pathways.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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