Animal StudyPubMed ID: 37224861·2023

Age-related decline in MOTS-c correlates with metabolic dysfunction in aging mice

Zhang H, Ryu D, Wu Y, et al.

GeroScience, 2023

Key finding

MOTS-c circulating levels declined 73% from young (4mo) to old (24mo) mice; restoration via adeno-associated viral delivery improved glucose tolerance by 34%.

Summary

Longitudinal study measuring MOTS-c levels throughout lifespan in mice, correlating decline with impaired glucose tolerance and mitochondrial dysfunction.

Read the study

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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