In VitroPubMed ID: 38506721·2024

MOTS-c cross-reactivity with other GPCR signaling: pharmacological profiling

Kim KH, Sripada L, Zhang K, et al.

Journal of Pharmacology and Experimental Therapeutics, 2024

Key finding

MOTS-c showed high selectivity; only significant interactions were with formyl peptide receptors (FPR1, IC50=420nM) and CXCR4 (IC50=890nM).

Summary

Comprehensive receptor profiling of MOTS-c against >150 human GPCRs, nuclear receptors, and ion channels to define specificity and potential off-target effects.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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