Animal StudyPubMed ID: 38457821·2024

Metabolic synergy: MOTS-c combined with nicotinamide riboside enhances NAD+ signaling

Zhang H, Yen K, Ryu D, et al.

Aging Cell, 2024

Key finding

MOTS-c + NR combination increased NAD+ levels 2.8-fold vs 1.6-fold for either agent alone; synergistic improvement in lifespan (11% extension) and healthspan.

Summary

Study examining combinatorial effects of MOTS-c and NR on NAD+ levels, sirtuin activation, and metabolic improvements in aged mice.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

More research on MOTS-c

Human pilot study: MOTS-c supplementation improves insulin sensitivity

Journal of Clinical Endocrinology & Metabolism · 2025 · Human Pilot

Mitochondrial-derived peptide MOTS-c mediates beneficial metabolic effects of exercise

Cell Reports · 2024 · Animal Study

MOTS-c analog development and pharmacokinetics: oral bioavailability enhancement

Biochemical Pharmacology · 2024 · Animal Study

MOTS-c enhances glucose uptake through AMPK-independent mechanisms in muscle

Metabolism: Clinical & Experimental · 2024 · Animal Study

MOTS-c and liver metabolism: effects on hepatic glucose production and lipid metabolism

Journal of Hepatology · 2024 · Animal Study