Animal StudyPubMed ID: 38624871·2024

MOTS-c and neuroinflammation: neuroprotective effects in neurodegeneration models

Sripada L, Zhang K, Kim SJ, et al.

Neurotherapeutics, 2024

Key finding

MOTS-c reduced neuroinflammatory cytokines (TNF-α 54%, IL-6 48%) in aged 5xFAD mice and improved spatial memory performance by 23%.

Summary

Investigation of MOTS-c effects in Alzheimer's disease and Parkinson's disease mouse models, measuring neuroinflammatory markers and neurodegeneration.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

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Related compound

MOTS-cL2

A mitochondria-derived peptide that targets the AMPK pathway, studied for metabolic regulation and exercise mimicry.

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