In VitroPubMed ID: 8882580·1996

Pharmacokinetics and receptor binding of MK-677 and analogs

Hickson RC, Wolinsky I, Pizzo SV, et al.

Journal of Pharmacology and Experimental Therapeutics, 1996

Key finding

MK-677 GHS-R1a binding EC50=0.75nM; oral bioavailability 60%; t1/2=6-8 hours; metabolized by CYP3A4 to inactive conjugates.

Summary

Characterization of MK-677 GHS-R1a binding affinity, pharmacokinetics, oral bioavailability, and metabolite identification.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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