Human RCTPubMed ID: 8923867·1996

MK-677 body composition in healthy elderly: fat-free mass and body fat distribution

Chapman IM, Bach MA, Van Cauter E, et al.

Journal of Clinical Endocrinology & Metabolism, 1996 · n = 24

Key finding

MK-677 increased fat-free mass by 1.4 kg (95% CI 0.2-2.6) and increased resting energy expenditure 11%; visceral fat unchanged.

Summary

Double-blind RCT in 24 healthy elderly subjects (65-82 years) measuring body composition changes with 10-day MK-677 administration.

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Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

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