Human RCTPubMed ID: 9467534·1998

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism

Murphy MG, Plunkett LM, Gertz BJ, et al.

Journal of Clinical Endocrinology & Metabolism, 1998 · n = 32

Key finding

MK-677 25mg daily reversed diet-induced nitrogen wasting by increasing GH pulse amplitude and IGF-1 levels.

Summary

RCT showing MK-677 reversed diet-induced protein catabolism by increasing GH and IGF-1 in healthy volunteers on caloric restriction.

Read the study

The full citation, abstract, and (when available) the full text can be accessed on PubMed. PeptideMark summaries are condensed overviews — we encourage researchers to read primary sources.

View on PubMed

Related compound

MK-677L4

An oral ghrelin mimetic (not a peptide) that stimulates growth hormone release. Has extensive human data but has not achieved FDA approval.

More research on MK-677

Growth hormone secretagogues as potential therapeutic agents to restore growth hormone secretion in older subjects

Journals of Gerontology: Series A · 2023 · Review

MK-677 and Alzheimer's disease: neuroprotection and cognitive decline in animal models

Journal of Alzheimer's Disease · 2012 · Animal Study

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

Annals of Internal Medicine · 2008 · Human RCT

MK-677 and cognitive function in aged subjects: memory and executive function

European Journal of Endocrinology · 2008 · Human Pilot

MK-677 in cachexia and wasting diseases: preclinical efficacy studies

Nutrition & Metabolism · 2008 · Animal Study